Uric Acid In Blood: Causes And Troubles

Now-a-days, those people, who're health conscious and choose regular health check- up, are acquainted with the phrase "uric acid ".But many of them do not know what it is and what forms of problems it may create within the body if it includes excess of this acid.

What is  Axit Uric ?

From the nucleic acid of the living cells, by different metabolic processes, two substances called adenine and guanine are produced which are called purine. A chemical within our body called xanthine-oxidase converts this purine, in three stages, to uric acid. Chemically, it consists of carbon, nitrogen, hydrogen and oxygen whose formula is C5H4N4O3. The salt of it is called sodium urate monohydrate. Once the decay of cells occurs at a rate greater compared to the normal rate, then the formation of uric acid in the torso also increases. The utmost permissible amount of it in the blood of an adult male is 8mg/100ml of blood while that in a grownup female is 6mg/100ml of blood. If its level in the blood is a lot more than the aforementioned maximum level, then it is called hyper-uricaemia, that is not just a normal condition. It sometimes appears that generally its level in the blood increases gradually after 20 years old and in the case of females this occurs, particularly, following the menopause. The sum total content of the acid in the blood may remain within 900mg - 1200mg with respect to the bodyweight, food habit and racial difference. 75% of it in our blood is excreted, unchanged, through urine, while 20 - 25% of it, changed somewhat, is excreted through the faeces. Uric acid within our blood is in the form of monosodium urate, which, if increases, gets deposited in the joints and kidneys and causes diseases.

How does hyper-uricaemia occur?

Hyper-uricaemia may occur due to one or more of the next reasons:

1) Increased formation of uric acid as a result of genetic characteristics or metabolic malfunctioning of enzymes.

2) Chronic kidney disease resulting in less excretion of the acid through urine.

3) An excessive amount of intake of meat (lamb, beef) or sea-fishes.

4) Eating of fructose-rich foods. Sugar contains about 50% fructose.

5) Drinking of corn syrup.

6) Diseases causing rapid cell turnover, like polycythaemia, different types of leukaemia and a skin disease called psoriasis.

7) Drinking too much alcohol, particularly, beer.

8) Daily intake of very low dose of aspirin. Too much intake of tea or medicine containing caffein.

9) Thiazide like medicines which are used to treat blood pressure and dropsy.

10) Medicines like pyrazinamide and ithambutol which are accustomed to treat tuberculosis.

11) Medicines like livodopa, methyldopa, cysplatin and cyclomerine.

12) When an overweight person tries to lose weight quickly, then there occurs a growth in the uric acid level in his/her blood.

13) While doing excessive physical work or exercise, there's an elevated formation of lactic acid in the body. During those times, there may be a temporary increased production of uric acid in the blood.

14) Type 2 diabetes, high blood pressure, obesity, insulin-resistant disease syndrome'x'- in all these cases the level of the acid is high.

Problems caused by high uric acid level in blood

This might cause mainly 2 types of diseases --

1) Gout

2) Uric acid stone in kidneys

Gout

Gout arthritis is produced by increased uric acid level in the blood caused by any disturbance in the body's purine or protein metabolism. Uric acid does not dissolve properly within our blood. So, any excess of it in the blood gets deposited in our joints in the proper execution of monosodium urate crystals and causes inflammation. Gout is a very painful disease of joints, which mainly occurs to aged persons. Males are 5-7 times more vulnerable to this disease compared to the females.

The situation starts when the amount of uric acid in the blood crosses its normal amount of 2-7mg/100ml. It is observed that the painful symptoms of gout arthritis start showing if this level in the event of females exceeds 3.5-5mg/100ml and in case of males 5-7mg/100ml. Again, in case of severe gout, the amount might be 20mg/100ml or more.

Axit Uric  in kidneys

When the amount of uric acid in the blood is very high, then the surplus amount after saturation, which does not dissolve in blood, starts depositing in the kidneys, since 75% of the acid is excreted from the human body through the kidneys. Once  Axit Uric  of urine is acidic, then your kidneys cannot dispose off the complete of uric acid through urine. Moreover, during summer, when the human body loses lot of water or those individuals, who drink very less level of water, for them there's possible of easily developing stone in the kidneys. You can not feel any trouble at the first stage of kidney stone. Even, it can't be detected by ordinary X-ray or scan since the urate stone is radiolucent. It might be detected by sonography only.